Studies towards the synthesis of the hypermodified nucleoside of rat liver phenylalanine transfer ribonucleic acid: improved synthesis of the base beta-hydroxywybutine.

@article{Itaya1998StudiesTT,
  title={Studies towards the synthesis of the hypermodified nucleoside of rat liver phenylalanine transfer ribonucleic acid: improved synthesis of the base beta-hydroxywybutine.},
  author={T. Itaya and T. Kanai},
  journal={Chemical & pharmaceutical bulletin},
  year={1998},
  volume={46 8},
  pages={
          1220-4
        }
}
  • T. Itaya, T. Kanai
  • Published 1998
  • Medicine, Chemistry
  • Chemical & pharmaceutical bulletin
  • An improved synthesis of the key intermediates (3 and 8) for the synthesis of beta-hydroxywybutines [[R-(R*,S*)]- and [S-(R*,R*)]-4], the most probable structures for the minor base from rat liver tRNA(Phe), has been achieved by the Wittig reaction between 1-benzyl-7-formylwye (1) and the phosphorane derived from (R)-2-[(methoxycarbonyl)amino]-3-(triphenylphosphonio)propanoate (10), followed by methylation, OsO4 oxidation, and cyclocondensation with COCl2 in the presence of pyridine. The… CONTINUE READING
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