Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives.

Abstract

Based on the previously reported discovery lead, 3-(cis-4-(4-(1H-indol-4-yl)piperazin-1-yl)cyclohexyl)-5-fluoro-1H-indole (2), a series of related arylpiperazin-4-yl-cyclohexyl indole analogs were synthesized then evaluated as 5-HT transporter inhibitors and 5-HT(1A) receptor antagonists. The investigation of the structure-activity relationships revealed… (More)
DOI: 10.1016/j.bmc.2008.05.075

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Cite this paper

@article{Zhou2008StudiesTT, title={Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives.}, author={Dahui Zhou and Ping Zhou and Deborah A. Evrard and Kristin L. Meagher and Michael Webb and Boyd L. Harrison and Donna M. Huryn and Jeannette Golembieski and Geoffrey A Hornby and Lee E. Schechter and Deborah Lea Smith and Terrance H. Andree and Richard E Mewshaw}, journal={Bioorganic & medicinal chemistry}, year={2008}, volume={16 14}, pages={6707-23} }