Studies to investigate the pharmacokinetic interactions between ranolazine and ketoconazole, diltiazem, or simvastatin during combined administration in healthy subjects.

@article{Jerling2005StudiesTI,
  title={Studies to investigate the pharmacokinetic interactions between ranolazine and ketoconazole, diltiazem, or simvastatin during combined administration in healthy subjects.},
  author={Markus Jerling and Bee-Lian Huan and Kwan Leung and Nancy Chu and Hisham Abdallah and Ziad Hussein},
  journal={Journal of clinical pharmacology},
  year={2005},
  volume={45 4},
  pages={422-33}
}
The interactions of ranolazine, a new antianginal compound, with inhibitors and substrates of the CYP3A isoenzyme family were studied in 1 open-label and 4 double-blind, randomized, multiple-dose studies. In healthy adult volunteers, the authors sought (1) to determine the steady-state pharmacokinetics, safety, and tolerability of immediate- and sustained-release ranolazine with and without ketoconazole, diltiazem, or simvastatin and (2) to evaluate the effect of ranolazine on the… CONTINUE READING

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