Studies on vaccination against bacillary dysentery. 2. Safety tests and reactogenicity studies on a live dysentery vaccine intended for use in field trials.

Abstract

In view of the encouraging results obtained in active mouse protection experiments, several batches of live oral vaccine prepared from streptomycin-dependent Shigella flexneri were tested in vitro for any indication of reversion to streptomycin-independence and in man for their reactogenicity.The in vitro tests provided no evidence of reversion.In man… (More)

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