Studies on topical thephorin therapy; index of sensitization and effectiveness as an antipruritic.

@article{Stritzler1950StudiesOT,
  title={Studies on topical thephorin therapy; index of sensitization and effectiveness as an antipruritic.},
  author={C. Stritzler},
  journal={The Journal of allergy},
  year={1950},
  volume={21 5},
  pages={
          432-41
        }
}
3 Citations
Appraisal of topical use of antihistamines.
The era of antihistaminic therapy was instituted in 1933 when Fourneau and Bovet 1 demonstrated that certain phenolic ethers had the property of counteracting the action of histamine in vivo and inExpand
Allergy to drugs (concluded).
Allergy to drugs.
  • E. Carr
  • Medicine
  • The New England journal of medicine
  • 1951
Further Consideration of Certain Drugs Urticaria due to penicillin has two features that deserve comment: It may subside while the drug is still being administered147 or fail to recur on readminist...

References

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Clinical and experimental evaluation of thephorin ointment.
TLDR
Evidence is presented that favors the theory that the inhibition of the histamine flare must be attributed to the anesthetic action of Thephorin Ointment on the sensory nerve endings of the skin, and it is inferred that its antipruritic effect is based on the same mechanism. Expand
DISSEMINATED AND CIRCUMSCRIBED NEURODERMATITIS TREATED WITH PHENINDAMINE (THEPHORIN
TLDR
Chemists have been and are still trying to find an ideal drug which will have little or no side effects and will produce better effects through penetration of the skin, and histamine has never been proved entirely responsible for all the allergic manifestations attributed to it. Expand
Reactions to the local use of thephorin.
TLDR
Lehmann proved-and Strauss in reviewing antihistamine therapy, stated-that Thephorin is a more potent local anesthetic than procaine, which suggests the possibility that its local action may be more that of a localAnesthetic than that of an anti-histaminic. Expand
Thephorin ointment in pruritic dermatoses.
TLDR
A large number of patients with an allergic back problem are receiving treatment with antihistaminics or histamine antagonists, and the use of these drugs is under investigation. Expand
Local therapy with pyribenzamine hydrochloride.
Pharmacological properties of a new antihistaminic, 2-methyl-9-phenyl-2,3,4,9-tetrahydro-l-pyridindene (thephorin) and derivatives.
  • G. Lehmann
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1948
Thephorin, 2-methyl-9-phenyl-2,3,4,9-tetrahydro-1-pyridindene, one of three closely related pyridindene derivatives studied, proved to be a potent antihistaminic on isolated guinea pig's ileum, inExpand
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