Studies on tissue and cellular distribution of indoleamine 2,3-dioxygenase 2: the absence of IDO1 upregulates IDO2 expression in the epididymis.

@article{Fukunaga2012StudiesOT,
  title={Studies on tissue and cellular distribution of indoleamine 2,3-dioxygenase 2: the absence of IDO1 upregulates IDO2 expression in the epididymis.},
  author={Masakazu Fukunaga and Yasuko Yamamoto and Misaki Kawasoe and Yuko Arioka and Yuki Murakami and Masato Hoshi and Kuniaki Saito},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2012},
  volume={60 11},
  pages={854-60}
}
Indoleamine 2,3-dioxygenase 1 (IDO1) catabolizes tryptophan to kynurenine at the first step of tryptophan metabolism. Recently, in addition to IDO1, a new isoform called IDO2 was identified. In this study, we examined the tissue expression pattern of IDO2 mRNA and the cellular localization of expressed IDO2 protein in mice. IDO1 mRNA expression was observed in the colon and epididymis, whereas IDO2 mRNA expression was found in the cerebral cortex, liver, kidney, and epididymis… CONTINUE READING
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