Studies on theobromine disposition in normal subjects. Alterations induced by dietary abstention from or exposure to methylxanthines.

@article{Drouillard1978StudiesOT,
  title={Studies on theobromine disposition in normal subjects. Alterations induced by dietary abstention from or exposure to methylxanthines.},
  author={D D Drouillard and Elliot S. Vesell and Barry H. Dvorchik},
  journal={Clinical pharmacology and therapeutics},
  year={1978},
  volume={23 3},
  pages={
          296-302
        }
}
Normal male volunteers on xanthine-restricted diets had a plasma theobromine (TB) half-life (t1/2) of 6.1 +/- 0.7 hr (mean +/- SEM), a TB metabolic clearance rate (MCR) of 113.8 +/- 6.8 ml/min (mean +/- SEM), and an apparent volume of distribution (aVd) of 59.9 +/- 7.8 L (mean +/- SEM) after a single oral dose of 6 mg/kg of TB. A two-week period of dietary abstention from methylxanthines shortened the mean plasma TB t1/2 by 33% and increased the mean MCR of TB by 59%, no change occurred in mean… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

Psychopharmacology of theobromine in healthy volunteers

  • Psychopharmacology
  • 2013
VIEW 2 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Pharmacokinetics of theobromine and its metabolites in rabbits

  • Journal of Pharmacokinetics and Biopharmaceutics
  • 1985
VIEW 2 EXCERPTS
CITES BACKGROUND & METHODS