Studies on the tumor promoting mechanism of hard and soft segment models of polyetherurethane: Tyr265 phosphorylation of connexin43 is a key step in the GJIC inhibitory reaction induced by polyetherurethane.

@article{Ichikawa2002StudiesOT,
  title={Studies on the tumor promoting mechanism of hard and soft segment models of polyetherurethane: Tyr265 phosphorylation of connexin43 is a key step in the GJIC inhibitory reaction induced by polyetherurethane.},
  author={Akira Ichikawa and Toshie Tsuchiya},
  journal={Journal of biomedical materials research},
  year={2002},
  volume={62 2},
  pages={157-62}
}
Gap junctional intercellular communication (GJIC) is inhibited by 4,4'-di(ethoxycarboamide) diphenylmethane (MDU) and polytetramethylene oxide 1000 (PTMO1000), which are model chemicals of hard and soft segments of polyetherurethane (PEU), respectively. In our previous study, we suggested that the inhibition of GJIC induced by MDU and PTMO1000 may lead to… CONTINUE READING