Studies on the thymus of non-obese diabetic (NOD) mice: effect of transgene expression.

@article{Oreilly1994StudiesOT,
  title={Studies on the thymus of non-obese diabetic (NOD) mice: effect of transgene expression.},
  author={Lorraine A O'reilly and Don Healey and E. Hatheway Simpson and Phillip Chandler and Troy Lund and Mary A. Ritter and Anne Cooke},
  journal={Immunology},
  year={1994},
  volume={82 2},
  pages={275-86}
}
The non-obese diabetic (NOD) mouse is a good model of insulin-dependent diabetes mellitus. Autoreactive T cells may play a fundamental role in disease initiation in this model, while disregulation of such cells may result from an abnormal thymic microenvironment. Diabetes is prevented in NOD mice by direct introduction of an E alpha d transgene (NOD-E) or a… CONTINUE READING