Studies on the site of the interaction between alpha 1-adrenoceptors and 5-HT2 receptors in rat tail arteries.

  • J. F. Marwood
  • Published 1988 in Journal of cardiovascular pharmacology
Isolated perfused rat tail arteries were used to examine the hypothesis that alpha 1-adrenoceptors and 5-HT2 receptors overlap on the vascular smooth muscle membrane. The effects of a series of Ca2+ uptake blockers on responses to 5-hydroxytryptamine (5-HT) and phenylephrine (PE) were determined. Mn2+ ion, which inhibits Ca2+ entry to cells, reduced the… CONTINUE READING