Studies on the role of NonA in mRNA biogenesis.

  title={Studies on the role of NonA in mRNA biogenesis.},
  author={Natalia Kozlova and Jos{\'e} Renato Garcia Braga and Josefin Lundgren and Jos{\'e} Rino and Patrick Young and Maria Carmo-Fonseca and Neus Visa},
  journal={Experimental cell research},
  volume={312 13},
The NonA protein of Drosophila melanogaster is an abundant nuclear protein that belongs to the DBHS (Drosophila behavior, human splicing) protein family. The DBHS proteins bind both DNA and RNA in vitro and have been involved in different aspects of gene expression, including pre-mRNA splicing, transcription regulation and nuclear retention of mRNA. We have used double-stranded RNA interference in Drosophila S2 cells to silence the expression of NonA and to investigate its role in mRNA… CONTINUE READING