Studies on the respiratory response to disturbances of acid-base balance, with deductions concerning the ionic composition of cerebral interstitial fluid.

@article{Fencl1966StudiesOT,
  title={Studies on the respiratory response to disturbances of acid-base balance, with deductions concerning the ionic composition of cerebral interstitial fluid.},
  author={Vladimir Fencl and Tracy B. Miller and John R. Pappenheimer},
  journal={The American journal of physiology},
  year={1966},
  volume={210 3},
  pages={
          459-72
        }
}
FENCL, V., T. B. MILLER, AND J. R. PAPPENHEIMER. Studies on the respiratory response to distwbances of acid-base balance, with deductions concerning the ionic cornposition of cerebral interstitial @id. Am. J. Physiol. 2 I o(3) : 459-472, I g66.-Respiratory responses to inhaled (202 were studied on five unanesthetized goats during chronic metabolic acidosis or alkalosis. Measurements were made of alveolar ventilation, pH, [HCOa-1, and [Cl-] of arterial plasma and CSF during each steady-state… 

Respiratory responses to medullary hydrogen ion changes in cats: different effects of respiratory and metabolic acidoses.

The steady‐state responses of respiration, measured as integrated phrenic nerve activity, to hypercapnic acidosis of the medullary extracellular fluid and to metabolically generated acidosis were compared in paralysed, vagotomized and glomectomized cats and it is concluded that the e.c.f. [H+] does not represent the unique stimulus to the central chemoreceptors.

Respiratory adjustment to chronic metabolic alkalosis in man.

Observations suggest that respiratory depression does not necessarily accompany extracellular alkalosis but depends on the effect of the mode of induction of the alkalinizing agents on the tissues involved in the control of ventilation.

The Extracellular Bicarbonate Concentration and the Regulation of Ventilation in Chronic Hypercapnia in Man

The “normal” or predicted HCO 3 − Pco2 relationship in individuals with chronic hypercapnia who are in normal electrolyte balance is investigated and the effect of chloride depletion, potassium chloride replacement, and ammonium chloride acidosis on the ventilatory responsiveness to inspired CO2 is investigated.

Regulation of the CSF pH in acute and sustained respiratory acidosis.

It is concluded that the regulation of the CSF pH in hypercapnia does not seem to require active transport of H+ or HCO3-.

Three compartments model for the bicarbonate exchange of the brain extracellular fluid with blood and cells.

No evidence is reported for a precise regulation of the pH in cisternal or lumbar CSF during respiratory alkalosis in high altitude acclimatization, and the question of how far the acid-base measurement in bulk CSF approximated the status in the brain extracellular fluid bathing the cells remains open.

Bicarbonate and chloride shifts in rat brain during acute and prolonged respiratory acid-base changes.

It is concluded that the chloride ion equilibrated between plasma and brain tissue under the conditions of the experiment and changed the bicarbonate concentration of CSF during respiratory changes in the acid-base equilibrium.

The role of chloride and other anions in cerebrospinal fluid bicarbonate regulation.

  • E. NattieL. Romer
  • Biology, Medicine
    Advances in experimental medicine and biology
  • 1978
As it has been shown that small changes in serum osmolarity can affect bulk flow of fluid into or out of the CSF6 it seems possible that changes in Serum osmolarsity could alter CSF bicarbonate regulation.

Acid–base balance and cerebrovascular regulation

Results substantiate two key ideas: first, that the regulation of CBF is affected by the severity of metabolic/respiratory disturbances, including the extent of partial/full acid–base compensation; and second, that it is independent of arterial pH and that diffusion of CO2 across the blood–brain barrier is integral to altering perivascular extracellular pH.
...

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