Studies on the respiratory chain-linked reduced nicotinamide adenine dinucleotide dehydrogenase. 13. Binding sites of rotenone, piericidin A, and amytal in the respiratory chain.

@article{Horgan1968StudiesOT,
  title={Studies on the respiratory chain-linked reduced nicotinamide adenine dinucleotide dehydrogenase. 13. Binding sites of rotenone, piericidin A, and amytal in the respiratory chain.},
  author={Douglas J. Horgan and Thomas Peter Singer and John E. Casida},
  journal={The Journal of biological chemistry},
  year={1968},
  volume={243 4},
  pages={
          834-43
        }
}
Abstract The binding sites of rotenone, piericidin A, and Amytal in the reduced nicotinamide adenine dinucleotide oxidase chain of heart have been studied with the aid of rotenone-6a-14C. Binding of rotenone continues in a linear manner beyond the point of maximal inhibition of respiration, indicating that rotenone is tightly bound not only at the specific site in the NADH dehydrogenase segment of the respiratory chain but also at other sites in submitochondrial particles. Unspecific binding is… CONTINUE READING

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