Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants.

@article{Yen1995StudiesOT,
  title={Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants.},
  author={Paul M Yen and Elizabeth Wilcox and Yoshitaka Hayashi and Samuel Refetoff and William Wei Lim Chin},
  journal={Endocrinology},
  year={1995},
  volume={136 7},
  pages={2845-51}
}
Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that regulate target gene transcription. Interestingly, in the absence of ligand, TRs also can repress basal transcription of positively regulated target genes, suggesting that unliganded TR may have a distinct role in gene regulation. In this paper, DNA binding, truncation, and natural human TR beta mutants were used in cotransfection and electrophoretic mobility shift assays to study various aspects of TR-mediated… CONTINUE READING