Studies on the preparation, crystal structure and bioactivity of ginsenoside compound K.

@article{Zhou2006StudiesOT,
  title={Studies on the preparation, crystal structure and bioactivity of ginsenoside compound K.},
  author={Wei Zhou and M Feng and J Li and Pei Zhou},
  journal={Journal of Asian natural products research},
  year={2006},
  volume={8 6},
  pages={519-27}
}
Microbial transformation of Panaxnotoginseng saponins (PNS) using Aspergillus niger afforded, as the main metabolite, ginsenoside compound K (20-O-beta-glucopyranosyl-20(S)-protopanaxadiol). Its structure was determined spectroscopically and by X-ray analysis, and this is the first time the crystal structure of ginsenoside has been reported. In comparison with ginsenoside Rb1, the pro-drug for this metabolite, compound K exhibits potent cytotoxic activity against tumor cell lines. The mean… CONTINUE READING

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