Studies on the physiological functions of thiamine. I. The effects of thiamine deficiency and thiamine antagonists on the oxidation of alpha-keto acids by rat tissues.

Although thiamine has been known and studied for many years, there is still much we do not know about its physiological functions and mechanism of action in biological systems, particularly in animal tissues. Earlier workers have shown that thiamine diphosphate (cocarboxylase) functions as a coenzyme in the metabolism of pyruvate and a-ketoglutarate (l-9… CONTINUE READING