Corpus ID: 29345544

Studies on the physiologic disposition and activity of phenylpropanolamines in the mouse.

@article{Levitt1974StudiesOT,
  title={Studies on the physiologic disposition and activity of phenylpropanolamines in the mouse.},
  author={M. Levitt and W. R. Cumiskey and L. Shargel},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1974},
  volume={2 2},
  pages={
          187-93
        }
}
The metabolism, distribution, uptake, release, and activity of m -aminophenylpropanolamine (MAPP), a nonphenolic amine, was studied in the mouse. Only a single radioactive peak was detected in urine after administration of tritiated MAPP. In distribution studies we found that tritiated MAPP and metaraminol (MA) were concentrated and retained in cardiac tissue compared to liver, spleen, kidney, and lung. Desipramine, cocaine, bretylium, and norepinephrine blocked the uptake of MAPP and MA into… Expand
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