Studies on the pathogenesis of the pseudohermaphroditism in the mouse with testicular feminization.

@article{Goldstein1972StudiesOT,
  title={Studies on the pathogenesis of the pseudohermaphroditism in the mouse with testicular feminization.},
  author={Joseph L Goldstein and J Douglas Wilson},
  journal={The Journal of clinical investigation},
  year={1972},
  volume={51 7},
  pages={1647-58}
}
The pathogenesis of the male pseudohermaphroditism in the mouse with X-linked testicular feminization (Tfm) has been investigated by comparing testosterone formation, the effects of androgen administration, and the metabolism of testosterone-1,2-(3)H in normal mice and Tfm mice of varying ages. First, it was established that the adult Tfm animal, in contrast to the human with testicular feminization, has both a low serum testosterone and a low rate of testosterone formation as assessed in… CONTINUE READING
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