Studies on the mode of action of vasopressin on the isolated proximal colon of the guinea‐pig

@article{Botting1969StudiesOT,
  title={Studies on the mode of action of vasopressin on the isolated proximal colon of the guinea‐pig},
  author={Jack Howard Botting and A D Turmer},
  journal={British Journal of Pharmacology},
  year={1969},
  volume={37}
}
1 . Contractions of guinea‐pig isolated proximal colon produced by vasopressin are not affected by methyloxytocin (a compound that blocks pressor effects of vasopressin). 2 . Vasopressin contractions are inhibited by replacement of sodium with mannitol or sucrose, elevation of potassium or magnesium concentrations, the presence of the metabolic inhibitors sodium azide and triethyl tin or tetrodotoxin in the bathing fluid. Contractions produced by histamine or choline esters are comparatively… 

The action of vasopression on the gastrointestinal tract

Recent advances in the knowledge of the metabolism of this hormone, as wel} as newer technics utilized for its study, warranted a general review of the literature on the effects of vasopressin on gastrointestinal tract morphology and function.

Monoamine oxidase histochemistry of enteric neurones in the guinea-pig

In the myenteric plexus of the small intestine, cells corresponding to Dogiel's type II were prominent whereas type I cells appeared less reactive for MAO, however, both type I and type II cells of the proximal colon were heavily stained.

Peptides: Other Hormones

The hypothalamus of most vertebrate species secretes two main peptides whose activities, though overlapping, fall into two different categories: pressor and uterine-contracting substances. In

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Experiments are described which provide evidence in support of the suggestion that vasopressin might be capable of effecting a contraction of this tissue by stimulating nervous elements associated with the smooth muscle.

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