Studies on the mode of action of vasopressin on the isolated proximal colon of the guinea‐pig

  title={Studies on the mode of action of vasopressin on the isolated proximal colon of the guinea‐pig},
  author={Jack Howard Botting and A D Turmer},
  journal={British Journal of Pharmacology},
1 . Contractions of guinea‐pig isolated proximal colon produced by vasopressin are not affected by methyloxytocin (a compound that blocks pressor effects of vasopressin). 2 . Vasopressin contractions are inhibited by replacement of sodium with mannitol or sucrose, elevation of potassium or magnesium concentrations, the presence of the metabolic inhibitors sodium azide and triethyl tin or tetrodotoxin in the bathing fluid. Contractions produced by histamine or choline esters are comparatively… 

The action of vasopression on the gastrointestinal tract

Recent advances in the knowledge of the metabolism of this hormone, as wel} as newer technics utilized for its study, warranted a general review of the literature on the effects of vasopressin on gastrointestinal tract morphology and function.

Monoamine oxidase histochemistry of enteric neurones in the guinea-pig

In the myenteric plexus of the small intestine, cells corresponding to Dogiel's type II were prominent whereas type I cells appeared less reactive for MAO, however, both type I and type II cells of the proximal colon were heavily stained.

Peptides: Other Hormones

The hypothalamus of most vertebrate species secretes two main peptides whose activities, though overlapping, fall into two different categories: pressor and uterine-contracting substances. In



Mode of action of vasopressin on isolated proximal colon of the guinea-pig.

Experiments are described which provide evidence in support of the suggestion that vasopressin might be capable of effecting a contraction of this tissue by stimulating nervous elements associated with the smooth muscle.

An analysis of the direct and indirect actions of drugs on the isolated guinea-pig ileum.

  • M. DayJ. Vane
  • Biology, Chemistry
    British journal of pharmacology and chemotherapy
  • 1963
It is concluded that morphine is only a partial antagonist of 5-hydroxytryptamine receptors in nervous tissue and that phenoxybenzamine antagonizes more 5-Hydroxyt Kryptamine receptors than those in smooth muscle.

Action of prostaglandin E 1 on the longitudinal muscle of the guinea-pig isolated colon.

Results suggested that prostaglandin E1 stimulated receptors on or in the muscle cells, and also activated non-cholinergic excitatory nerves in guinea-pig ileum and found that nicotine and dimethylphenylpiperazinium iodide produce contractions in the presence of hyoscine.

Some effects of calcium and magnesium ions on guinea‐pig uterine muscle

The results show that whereas calcium ions increase all three indices of uterine activity, and may therefore act at a site controlling both the spontaneous contractions and the responses to the two stimulants, magnesium ions act in some respects synergically and in others antagonistically.


The purpose of this investigation was to define, if possible, the conditions under which the dioestrus uterus of the rat can be used reliably to assay oxytocin contained in extracts of powders made from whole posterior lobes of the pituitary body.

The effect of morphine on vagal inhibition of the heart.

In the guinea-pig, morphine had no inhibitory effect and in the cat the effect was small, but in the rat and the rabbit stimulation of the vagus slowed the heart much less after administration of morphine than before.

The effect on intracellular atrial potentials of bretylium in relation to its local anaesthetic potency.

Although the idea that prostaglandin E1 acts partly by stimulating non-cholinergic excitatory nerves is favoured, the possibility that tetrodotoxin acts atypically, for example by interfering with the excitation of prostag landin receptors on the muscle, cannot be excluded.

The atropine-resistance of the response to intrinsic nerve stimulation of the guinea-pig bladder.

Studies on the response of the isolated bladder of the guinea-pig to electrical stimulation and to application of drugs are described.

The effect of some 2-O-alkyltyrosine analogues of oxytocin and lysine vasopressin on the blood pressure of the rat, rabbit, and cat.

The results obtained in a more detailed study of the effects of these 0-alkylated analogues on the blood pressure of the rat, cat, and rabbit under various conditions are reported.

The “nicotinic” and “muscarinic” receptors of the urinary bladder of the guinea‐pig

The results indicate that the nicotinic receptors are confined to nervous tissue, and do not support the suggestion that there might be non‐neuronal nicotinics receptors in the bladder musculature of the guinea‐pig.