Studies on the metabolism of retinol and retinol-binding protein in transthyretin-deficient mice produced by homologous recombination.

@article{Wei1995StudiesOT,
  title={Studies on the metabolism of retinol and retinol-binding protein in transthyretin-deficient mice produced by homologous recombination.},
  author={Shipeng Wei and Vasso Episkopou and Roseann Piantedosi and Shin Maeda and Kohei Shimada and Max E. Gottesman and William S. Blaner},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 2},
  pages={866-70}
}
Tissue needs for retinoids are believed to be satisfied through the delivery in the circulation of retinol by its specific plasma transport protein, retinol-binding protein (RBP), which circulates as a 1-to-1 protein complex with transthyretin (TTR). The binding of RBP to TTR is thought to prevent filtration of retinol-RBP in the kidney and to play a role in secretion of RBP from hepatocytes. Recently a strain of mice (TTR-) that totally lacks immunoreactive TTR was produced by targeted… CONTINUE READING

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