Studies on the mechanisms by which insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) and IGFBP-5 modulate IGF actions in bone cells.

@article{Mohan1995StudiesOT,
  title={Studies on the mechanisms by which insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) and IGFBP-5 modulate IGF actions in bone cells.},
  author={Subburaman Mohan and Yoko K. Nakao and Yoshiomi Honda and E. C. Landale and Ulrike Leser and Carola Dony and Kurt Lang and David J. Baylink},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 35},
  pages={20424-31}
}
The growth potentiating effects of the insulin-like growth factor (IGF)-I and IGF-II are modulated by a family of six insulin-like growth factor binding proteins (IGFBPs). Despite the similarity in amino acid sequences of the IGFBPs, their effects on the growth of bone cells differ. Studies on the molecular mechanisms for IGFBP-4 actions revealed that coincubation of bone cells with IGFBP-4 and 125I-IGF-I or 125I-IGF-II decreased the binding of both of these ligands in a dose-dependent manner… CONTINUE READING

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