Corpus ID: 9086141

Studies on the mechanism of positive inotropic effect of hymoquinolone.

@article{Xu1992StudiesOT,
  title={Studies on the mechanism of positive inotropic effect of hymoquinolone.},
  author={S B Xu and Li Yue and K H Long and Y. C. Lin},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1992},
  volume={14 6},
  pages={
          441-4
        }
}
  • S. Xu, L. Yue, +1 author Y. C. Lin
  • Published 1 July 1992
  • Biology, Medicine
  • Methods and findings in experimental and clinical pharmacology
Mechanism of positive inotropic action of hymoquinolone (7-hydroxy-8-methoxy-4(1H)-quinolone) (Q), a new compound isolated from Chinese Soft Sinularia polydactyla and Sinularia lettoclados, was studied using radioimmunoassay. Q caused positive inotropic action accompanied by elevated cAMP level in left and right atria of guinea pig at the concentration of 0.34 mM. The evidence that Q inhibited phosphodiesterase activity and did not affect adenylate cyclase activity led to the conclusion that Q… Expand

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