Studies on the mechanism of action of picrotoxinin and other convulsants at the crustacean muscle GABA receptor.

@article{Smart1986StudiesOT,
  title={Studies on the mechanism of action of picrotoxinin and other convulsants at the crustacean muscle GABA receptor.},
  author={Trevor G Smart and Andrew Constanti},
  journal={Proceedings of the Royal Society of London. Series B, Biological sciences},
  year={1986},
  volume={227 1247},
  pages={191-216}
}
The actions of picrotoxinin, bicuculline and penicillin-G were investigated on the GABA-receptor system of lobster muscle by using intracellular recording. The highly potent antagonist, picrotoxinin, produced a lateral shift and depression in the maximum of the GABA dose--conductance curve (designated as mixed antagonism); bicuculline, a weak antagonist, caused only a depression in the maximum with little or no lateral shift, whereas penicillin-G, an even weaker antagonist, produced a greater… CONTINUE READING

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