Corpus ID: 28274058

Studies on the mechanism of action of glucagon on gluconeogenesis.

  title={Studies on the mechanism of action of glucagon on gluconeogenesis.},
  author={Michio Ui and Thomas Harrison Claus and John H. Exton and C. R. Park},
  journal={The Journal of biological chemistry},
  volume={248 15},
  • Michio Ui, Thomas Harrison Claus, +1 author C. R. Park
  • Published 1973
  • Biology, Medicine
  • The Journal of biological chemistry
  • Abstract The mechanism by which glucagon stimulates gluconeogenesis was studied in livers perfused with 1 mm lactate, 0.1 mm pyruvate, and several different 14C-labeled substrates. In livers perfused for 2½ min with [14C]lactate plus [14C]-pyruvate, glucagon increased [14C]glucose synthesis 3-fold, increased the labeling of tissue P-pyruvate, aspartate, alanine, and glycogen, and decreased the labeling of pyruvate, oxalacetate, malate, citrate, α-ketoglutarate, and glutamate. The hormone also… CONTINUE READING

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