Studies on the mechanism of action of diallyl sulfide, an inhibitor of the genotoxic effects of cyclophosphamide.

@article{Goldberg1987StudiesOT,
  title={Studies on the mechanism of action of diallyl sulfide, an inhibitor of the genotoxic effects of cyclophosphamide.},
  author={M. Goldberg and P. D. Josephy},
  journal={Canadian journal of physiology and pharmacology},
  year={1987},
  volume={65 3},
  pages={
          467-71
        }
}
Diallyl sulfide, a component of garlic oil, has been previously shown to inhibit induction of nuclear aberrations in the colons of mice treated with 1,2-dimethylhydrazine, a colon carcinogen. The ability of this agent to block cyclophosphamide-induced nuclear aberrations in urinary bladder and hair follicles was tested. [14C]Cyclophosphamide was injected and urine was collected to determine the disposition of metabolites of cyclophosphamide in mice treated with diallyl sulfide. This agent was… Expand
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Nuclear aberrations in hair follicle cells of patients receiving cyclophosphamide
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