Studies on the mechanism of action of acetylcholine antagonists on rat parasympathetic ganglion cells.

@article{Ascher1979StudiesOT,
  title={Studies on the mechanism of action of acetylcholine antagonists on rat parasympathetic ganglion cells.},
  author={Philippe Ascher and William A. Large and Humphrey P Rang},
  journal={The Journal of physiology},
  year={1979},
  volume={295},
  pages={139-70}
}
The mode of action of ACh antagonists on the parasympathetic neurones of the submandibular ganglion of the rat was studied by means of a two-micro-electrode voltage-clamp technique. The currents produced by various agonists (carbachol, ACh, suberylcholine) were studied in steady state and after voltage steps, before and after perfusion of various antagonists. 2. For three antagonists (tubocurarine, hexamethonium, decamethonium) the blocking action increases with hyperpolarization. For three… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 58 extracted citations

Similar Papers

Loading similar papers…