Studies on the interaction of 4-quinolones with DNA by DNA unwinding experiments.


It has been recently found that, contrary to prior belief, norfloxacin, a member of the 4-quinolone family of antibacterial drugs that specifically inhibit DNA gyrase, does not bind to the enzyme but instead to DNA. We have performed DNA unwinding experiments in order to decide whether binding of norfloxacin to DNA introduces changes in its supercoiled… (More)


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