Studies on the interaction between GP-18-0-deficient neutrophils and vascular endothelium.

@article{Buchanan1982StudiesOT,
  title={Studies on the interaction between GP-18-0-deficient neutrophils and vascular endothelium.},
  author={Michael Buchanan and Cheryl Crowley and Richard E. Rosin and Michael A. Gimbrone and Bernard M . Babior},
  journal={Blood},
  year={1982},
  volume={60 1},
  pages={
          160-5
        }
}
A patient whose neutrophils lack the glycoprotein gp-180 shows an increased susceptibility to bacterial infections. Neutrophils from this patient migrate abnormally both in vivo and in vitro. To examine the basis for this abnormality in migration, a study was carried out on the interaction of gp-180-deficient neutrophils with artificial surfaces and with human endothelial cell cultures. Compared with normal neutrophils. gp-180-deficient neutrophils showed decreased adhesion to cold-insoluble… CONTINUE READING

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