Studies on the interaction between hyaluronan and a rat colon cancer cell line

@article{Samuelsson1998StudiesOT,
  title={Studies on the interaction between hyaluronan and a rat colon cancer cell line},
  author={Carolina Samuelsson and Stefan Gustafson},
  journal={Glycoconjugate Journal},
  year={1998},
  volume={15},
  pages={169-175}
}
Binding studies with 125I-Tyr labelled hyaluronan (HA) on a cultured rat colon cancer cell line were performed to characterize the association of HA to tumour cells in vitro. Results show a specific and saturable binding (Kd= 1.36nM) which indicates the presence of an HA binding receptor on the tumour cells. There is a specific constant increase of cell-associated HA over time, which indicates that HA is specifically taken up by the cells through endocytosis. The binding of 125I-Tyr labelled HA… CONTINUE READING
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Referenced Papers

Publications referenced by this paper.
Showing 1-3 of 3 references

1rends Glycosci Glycotech 8: 1—9

  • S Gustafson
  • Curr Opin ̧ip
  • 1996

In First International 1⁄4orkshop on Hyaluronan in Drug Delivery (Willoughby DA, ed.) pp 43—59

  • S Gustafson, N Forsberg, P McCourt, T Wikström, T Björkman, K Lilja
  • 1994

Faseb J 6: 2397—404

  • L Sherman, J Sleeman, P Herrlich, H Ponta
  • Curr Opin Cell Biol
  • 1992

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