Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3).

@article{Kaptein2000StudiesOT,
  title={Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3).},
  author={Allard Kaptein and Marilyn Jansen and G{\"o}n{\"u}l Dilaver and Jeremy Kitson and Laura Dash and Enhua Wang and Michael J Owen and J. L. Bodmer and J. -M. Tschopp and Stuart N. Farrow},
  journal={FEBS letters},
  year={2000},
  volume={485 2-3},
  pages={135-41}
}
WSL-1/TRAMP (DR3) is a member of the tumour necrosis factor (TNF) receptor superfamily which exhibits effects on NF-kappaB activation and apoptosis. TWEAK, a novel TNF-related molecule, has been proposed as the ligand for this receptor. Utilising both human and murine TWEAK ligand, it is shown that TWEAK and WSL-1/TRAMP do not interact in an in vitro binding assay and that TWEAK binds strongly to cells that do not express WSL-1/TRAMP on the cell surface. Biological activity of TWEAK is also… CONTINUE READING
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