• Corpus ID: 40663869

Studies on the inter-relationship of certain cholinergic compounds. V. The significance of the actions of the 3-hydroxy phenyltrimethylammonium ion on neuromuscular function.

  title={Studies on the inter-relationship of certain cholinergic compounds. V. The significance of the actions of the 3-hydroxy phenyltrimethylammonium ion on neuromuscular function.},
  author={Walter F. Riker and W. Clarke Wescoe},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={100 4:1},
  • W. Riker, W. Wescoe
  • Published 1 October 1950
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
1. A method is described which provides a simple means for the quantitative evaluation of a curariform action in the anesthetized surgical patient. 2. The anti-curare actions of 3-hydroxy phenyltrimethylammonium bromide (Nu 2561), 3-acetoxy phenyltrimethylammonium methylsulfate (Nu 2107) and 3-hydroxy phenyldimethylethylammonium bromide (Ro 2-3198) were evaluated in anesthetized man. Each of these agents proved to be an effective antagonist to d-tubocurarine chloride. The dose-response curves… 
Effect of Tensilon in Myasthenia Gravis
The present series includes a total of 13 patients with myasthenia gravis and four controls, all of whom were given Tensilon, one of the quaternary ammonium salts which have been shown to exert a direct stimulatory effect on the neuromuscular junction.
A clinical evaluation of pyridostigmin bromide in the reversal of curarization
SummaryPyridostigmin bromide in doses of 10 to 20 mg is an effective antagonist of d-tubocurarine when used in the presence of cyclopropane, diethyl ether, methoxyflurane, nitrous oxide, or
  • E. Emery
  • Medicine
    British journal of anaesthesia
  • 1963
Although it is difficult to classify drugs accurately according to their pharmacological action at the neuromuscular junction, they may be grouped under the following headings: drugs influencing the release or metabolism of acetylcholine, and drugs affecting the metabolism and excretion of muscle relaxants.
The Effects of Facilitatory Drugs at the Skeletal Neuromuscular Junction Using Intracellular End-Plate Recordings
The effects of facilitatory drugs (neostigmine, edrophonium, amben~: , ' onium and methoxyambenonium) at the skeletal neuromuscular junction have been studied using intracellular microelectrodes in
During the past two decades the neuromuscular blocking drugs have proved to be an exceedingly popular subject for pharmacological and physiological study. Oddly, the opposite aspect, that is, the
Guest Discussion
average dose of gallamine used was 0.81 mg./kg./hr.; that of curare was 0.11 mg./ kg./hr. In the gallamine series the dosage of pyridostigmine necessary to reverse neuromuscular block ranged from 2
Anticholinesterase-resistant neuromuscular blockade in sheep given amino-steroid muscle relaxants
Three cases of anticholinesterase-resistant neuromuscular blockade in sheep are described and the effects of relative overdose were probably augmented by the sensitivity of sheep to non-depolarizing neuromUScular blocking agents and the relative insensitivity of monitoring blockade using tactile and visual evaluation of evoked responses.
Pharmacologic considerations in a reevaluation of the neuromuscular synapse.
  • W. Riker
  • Psychology, Medicine
    Archives of neurology
  • 1960
A pivotal advance in the physiology of neuromuscular transmission was made when Brown et al. (1936) observed for the first time the characteristic action of physostigmine in augmenting the isometric
Contributions to medicine by research in pharmacology. Some aspects of dosage.
The dose-response relationship is reviewed, namely, the dose- response relationship, to call to attention its meaning, its importance and its role in pharmacology.
Use of Pyridostigmine for the Reversal of Neuromuscular Blockade
In the treatment of myasthenia gravis, oral neostIGmine bromide has in large measure been replaced by pyridostigmine Bromide, which produces fewer gastrointestinal side effects, has a longer duration of action, and gives a more even level of sustained muscle strength.