• Corpus ID: 40663869

Studies on the inter-relationship of certain cholinergic compounds. V. The significance of the actions of the 3-hydroxy phenyltrimethylammonium ion on neuromuscular function.

@article{Riker1950StudiesOT,
  title={Studies on the inter-relationship of certain cholinergic compounds. V. The significance of the actions of the 3-hydroxy phenyltrimethylammonium ion on neuromuscular function.},
  author={Walter F. Riker and W. Clarke Wescoe},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1950},
  volume={100 4:1},
  pages={
          454-64
        }
}
  • W. Riker, W. Wescoe
  • Published 1 October 1950
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
1. A method is described which provides a simple means for the quantitative evaluation of a curariform action in the anesthetized surgical patient. 2. The anti-curare actions of 3-hydroxy phenyltrimethylammonium bromide (Nu 2561), 3-acetoxy phenyltrimethylammonium methylsulfate (Nu 2107) and 3-hydroxy phenyldimethylethylammonium bromide (Ro 2-3198) were evaluated in anesthetized man. Each of these agents proved to be an effective antagonist to d-tubocurarine chloride. The dose-response curves… 
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