• Corpus ID: 40663869

Studies on the inter-relationship of certain cholinergic compounds. V. The significance of the actions of the 3-hydroxy phenyltrimethylammonium ion on neuromuscular function.

  title={Studies on the inter-relationship of certain cholinergic compounds. V. The significance of the actions of the 3-hydroxy phenyltrimethylammonium ion on neuromuscular function.},
  author={Walter F. Riker and W. Clarke Wescoe},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={100 4:1},
  • W. RikerW. Wescoe
  • Published 1 October 1950
  • Medicine
  • The Journal of pharmacology and experimental therapeutics
1. A method is described which provides a simple means for the quantitative evaluation of a curariform action in the anesthetized surgical patient. 2. The anti-curare actions of 3-hydroxy phenyltrimethylammonium bromide (Nu 2561), 3-acetoxy phenyltrimethylammonium methylsulfate (Nu 2107) and 3-hydroxy phenyldimethylethylammonium bromide (Ro 2-3198) were evaluated in anesthetized man. Each of these agents proved to be an effective antagonist to d-tubocurarine chloride. The dose-response curves… 

Effect of Tensilon in Myasthenia Gravis

The present series includes a total of 13 patients with myasthenia gravis and four controls, all of whom were given Tensilon, one of the quaternary ammonium salts which have been shown to exert a direct stimulatory effect on the neuromuscular junction.

A clinical evaluation of pyridostigmin bromide in the reversal of curarization

SummaryPyridostigmin bromide in doses of 10 to 20 mg is an effective antagonist of d-tubocurarine when used in the presence of cyclopropane, diethyl ether, methoxyflurane, nitrous oxide, or

The Effects of Facilitatory Drugs at the Skeletal Neuromuscular Junction Using Intracellular End-Plate Recordings

The effects of facilitatory drugs at the skeletal neuromuscular junction have been studied using intracellular microelectrodes in the isolated tenuissimus muscle of the cat to produce small changes in miniature end-plate potentials and iontophoretic acetylcholine-potentials.


A mechanism by which physostigmine and similar drugs cause the junctional region to initiate repetitive discharges in response to individual nerve volleys is disclosed and is often considered synonymous with ChE inhibition.

Guest Discussion

PyridostIGmine represents a safe alternative to neostigmine in the reversal of neuromuscular blockade induced by curariform agents and there were no cases of recurarization after reversal.

Anticholinesterase-resistant neuromuscular blockade in sheep given amino-steroid muscle relaxants

Three cases of anticholinesterase-resistant neuromuscular blockade in sheep are described and the effects of relative overdose were probably augmented by the sensitivity of sheep to non-depolarizing neuromUScular blocking agents and the relative insensitivity of monitoring blockade using tactile and visual evaluation of evoked responses.

Pharmacologic considerations in a reevaluation of the neuromuscular synapse.

  • W. Riker
  • Medicine, Biology
    Archives of neurology
  • 1960
A pivotal advance in the physiology of neuromuscular transmission was made when Brown et al. (1936) observed for the first time the characteristic action of physostigmine in augmenting the isometric

Contributions to medicine by research in pharmacology. Some aspects of dosage.

The dose-response relationship is reviewed, namely, the dose- response relationship, to call to attention its meaning, its importance and its role in pharmacology.

Use of Pyridostigmine for the Reversal of Neuromuscular Blockade

In the treatment of myasthenia gravis, oral neostIGmine bromide has in large measure been replaced by pyridostigmine Bromide, which produces fewer gastrointestinal side effects, has a longer duration of action, and gives a more even level of sustained muscle strength.

Actions at Autonomic Effector Sites

It is obvious that the anticholinesterase (anti-ChE) agents, by interference with these cholinergic phenomena, may produce profound and widespread changes in the function of the autonomic nervous system.