Studies on the inter-relationship of certain cholinergic compounds. V. The significance of the actions of the 3-hydroxy phenyltrimethylammonium ion on neuromuscular function.
@article{Riker1950StudiesOT, title={Studies on the inter-relationship of certain cholinergic compounds. V. The significance of the actions of the 3-hydroxy phenyltrimethylammonium ion on neuromuscular function.}, author={Walter F. Riker and W. Clarke Wescoe}, journal={The Journal of pharmacology and experimental therapeutics}, year={1950}, volume={100 4:1}, pages={ 454-64 } }
1. A method is described which provides a simple means for the quantitative evaluation of a curariform action in the anesthetized surgical patient.
2. The anti-curare actions of 3-hydroxy phenyltrimethylammonium bromide (Nu 2561), 3-acetoxy phenyltrimethylammonium methylsulfate (Nu 2107) and 3-hydroxy phenyldimethylethylammonium bromide (Ro 2-3198) were evaluated in anesthetized man. Each of these agents proved to be an effective antagonist to d-tubocurarine chloride. The dose-response curves…
19 Citations
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