Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metabolite.

@article{Subramanyam1991StudiesOT,
  title={Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metabolite.},
  author={Bhadriraju Subramanyam and T Woolf and Jr. Neal Castagnoli},
  journal={Chemical research in toxicology},
  year={1991},
  volume={4 1},
  pages={
          123-8
        }
}
Evidence that partially oxidized piperidine derivatives such as the Parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are biotransformed in a reaction catalyzed by monoamine oxidase B (MAO-B) to neurotoxic pyridinium metabolites led to studies resulting in the identification of the haloperidol-derived pyridinium metabolite in the urine of drug-treated rats. The present in vitro studies examine the metabolic pathway governing this overall four-electron oxidation… CONTINUE READING

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