• Corpus ID: 43641057

Studies on the hypothermic response of capsaicin and its analogue in mice.

  title={Studies on the hypothermic response of capsaicin and its analogue in mice.},
  author={T Fujii and Yumi Ohbuchi and S. Takahashi and Tsukasa Sakurada and Shinobu Sakurada and Ryuichiro Ando and Kensuke Kisara},
  journal={Archives internationales de pharmacodynamie et de therapie},
  volume={280 1},
Administration of capsaicin (CAP) and its related pungent, nonanoyl vanillylamide (NVA) produced significant dose-dependent hypothermic response in mice at an ambient temperature of 24 degrees C. CAP was approximately equieffective to NVA in producing hypothermia. After large doses, desensitization occurred to the hypothermic effects of both CAP and NVA. The hypothermia produced by CAP and NVA was prevented by a small dose of thyrotropin-releasing hormone (TRH) (0.25 nmol/animal) which by… 
1 Citations

Comparison of the Effects of Pelargonic Acid Vanillylamide and Capsaicin on Human Vanilloid Receptors

Voltage‐clamp recordings are performed using cells transfected with the human vanilloid receptor TRPV1 in order to assess the responses of pelargonic acid vanillylamide and capsaicin at the receptor level and suggest that the different effects of the two Capsaicinoids observed in previous studies may be due to different physicochemical or pharmacokinetic properties than to different pharmacological profiles at the receptors.