Studies on the hepatic alpha 1-adrenergic receptor. Modulation of guanine nucleotide effects by calcium, temperature, and age.

@article{Lynch1985StudiesOT,
  title={Studies on the hepatic alpha 1-adrenergic receptor. Modulation of guanine nucleotide effects by calcium, temperature, and age.},
  author={Christopher J. Lynch and Robert P. Charest and Peter F. Blackmore and John H. Exton},
  journal={The Journal of biological chemistry},
  year={1985},
  volume={260 3},
  pages={1593-600}
}
The effects of guanine nucleotides on the hepatic alpha 1-adrenergic receptor were studied using norepinephrine (NE) displacement of [3H]prazosin binding to rat liver plasma membranes. Nonhydrolyzable GTP analogues caused large rightward shifts of norepinephrine displacement curves of [3H]prazosin binding in EGTA-treated membranes, but only small shifts in… CONTINUE READING