Studies on the glomerular microcirculatory actions of manidipine and its modulation of the systemic and renal effects of endothelin.

@article{Takahashi1993StudiesOT,
  title={Studies on the glomerular microcirculatory actions of manidipine and its modulation of the systemic and renal effects of endothelin.},
  author={Kenzo Takahashi and Tetsuo Katoh and Masahiro Fukunaga and Kamal F. Badr},
  journal={American heart journal},
  year={1993},
  volume={125 2 Pt 2},
  pages={609-19}
}
We examined the actions of intravenously administered manidipine on systemic and renal microcirculatory hemodynamics and its efficacy in antagonizing endothelin-1 (ET-1)-evoked responses. Manidipine was a potent vasodilator with preferential activity in the renal vasculature. Its administration in optimal doses resulted in decreases in systemic arterial pressures accompanied by increases in renal perfusion and filtration rates. Its primary sites of action in the kidney were at both pre- and… CONTINUE READING