Studies on the excitatory and inhibitory influence of intracerebroventricularly injected opioids on seizure thresholds in rats.

@article{Tortella1984StudiesOT,
  title={Studies on the excitatory and inhibitory influence of intracerebroventricularly injected opioids on seizure thresholds in rats.},
  author={Frank C. Tortella and A. A. Cowan and Martin W. Adler},
  journal={Neuropharmacology},
  year={1984},
  volume={23 7A},
  pages={749-54}
}
The influence of centrally administered meperidine, normeperidine and pentazocine on the excitability of brain was studied by measuring the threshold for flurothyl-induced convulsions in rats. All three opioids are reported to lower seizure thresholds when given subcutaneously to rats in this test. Dose-and time-dependent changes in the seizure threshold occurred after intracerebroventricular injection of pentazocine (10-160 micrograms), meperidine (25-150 micrograms) and normeperidine (50-150… CONTINUE READING

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