Studies on the enhancement of 5-hydroxytryptamine-mediated behaviour by chlormethiazole and phenytoin.

@article{Green1992StudiesOT,
  title={Studies on the enhancement of 5-hydroxytryptamine-mediated behaviour by chlormethiazole and phenytoin.},
  author={Alfred Richard Green and Russell J de Souza and Alan J. Cross},
  journal={Journal of psychopharmacology},
  year={1992},
  volume={6 3},
  pages={370-5}
}
Pre-treatment of rats with chlormethiazole (35 mg/kg) or diphenylhydantoin (phenytoin: 40 mg/kg) markedly enhanced the behavioural syndrome which is induced by injection of tranylcypromine (10 mg/kg) followed by L-tryptophan (50 mg/kg). Phenobarbitone (35 mg/kg) pre-treatment was without effect on the syndrome. This enhancement apparently involved a pre-synaptic mechanism since pre-treatment with chlormethiazole or phenytoin did not result in enhancement of the behavioural syndrome when it was… CONTINUE READING