Corpus ID: 8056908

Studies on the effect of low dose methotrexate on rat adjuvant arthritis.

  title={Studies on the effect of low dose methotrexate on rat adjuvant arthritis.},
  author={W. L. Welles and J. Silkworth and A. Oronsky and S. Kerwar and J. Galivan},
  journal={The Journal of rheumatology},
  volume={12 5},
  • W. L. Welles, J. Silkworth, +2 authors J. Galivan
  • Published 1985
  • Medicine
  • The Journal of rheumatology
  • Adjuvant arthritis in rats was induced by the intradermal administration of Freund's complete adjuvant. When these immunized rats were treated orally with low doses of methotrexate (150-600 micrograms/kg/week) a statistically significant suppression of paw inflammation was observed. This low dose of methotrexate was comparable to that used in the treatment of human rheumatoid arthritis (RA). Our results are the first demonstration of the efficacy of low dose methotrexate in an animal model of… CONTINUE READING
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    • 12
    • Open Access