Studies on the de novo biosynthesis of NAD in Escherichia coli. V. Properties of the quinolinic acid synthetase system.

  title={Studies on the de novo biosynthesis of NAD in Escherichia coli. V. Properties of the quinolinic acid synthetase system.},
  author={Nobuo Suzuki and J Carlson and Gary R. Griffith and R. K. Gholson},
  journal={Biochimica et biophysica acta},
  volume={304 2},
1 Citations
Evidence for an intermediate in quinolinate biosynthesis in Escherichia coli
Results of these experiments indicate that the nadB gene product forms an unstable compound from aspartate in the presence of flavine adenine dinucleotide, and that this compound is then condensed with dihydroxyacetone phosphate to form quinolinate in a reaction catalyzed by the n adA gene product.
Isolation of a metabolite capable of differentially supporting the growth of nicotinamide adenine dinucleotide auxotrophs of Escherichia coli
A compound, isolated from the culture fluid of a nadC auxotroph of Escherichia coli grown in a minimal medium, supports the growth of both a nnA and a ndB mutant, which may be the precursor of quinolinic acid, an intermediate in the biosynthesis of nicotinamide adenosine dinucleotide.
Pyruvate production in Candida glabrata: manipulation and optimization of physiological function
Abstract Candida glabrata, a multi-vitamin auxotrophic yeast, can accumulate a large amount of pyruvate extracellularly using glucose as the carbon source, a characteristic that has facilitated the
NAD+ Biosynthesis and Signaling in Plants
A synthesis of a number of molecular genetic studies as well as biochemical analyses that have begun to elucidate the regulatory hierarchies both of NAD+ biosynthesis and the parallel activities of the enzymes that are involved in these pathways are presented.
Structural Features of the Phosphoribosyl-Transferases and Their Relationship to the Human Deficiency Disorders of Purine and Pyrimidine Metabolis
It is proposed that metabolic diseases of purine and pyrimidine metabolism are the consequence of structural mutations to an architectural domain common to all of the phosphoribosyltransferases.
The genome of Prasinoderma coloniale unveils the existence of a third phylum within green plants
Reconstruction of the minimal core genome of Viridiplantae allowed identification of an ancestral toolkit of transcription factors and flagellar proteins, which provides first insights into the dawn of green plant evolution.
Etude structurale et fonctionnelle de la quinolinate synthase : une protéine fer-soufre cible d'agents antibactériens
La Quinolinate synthase (NadA) catalyse la condensation de l’iminoaspartate et de la dihydroxyacetone phosphate aboutissant a la formation d’acide quinolinique, un intermediaire central dans la