Studies on the cytostatic and cytotoxic effects and mode of action of 8-nitro-7-hydroxycoumarin.

  title={Studies on the cytostatic and cytotoxic effects and mode of action of 8-nitro-7-hydroxycoumarin.},
  author={D. Egan and P. James and D. Cooke and R. O'Kennedy},
  journal={Cancer letters},
  volume={118 2},
  • D. Egan, P. James, +1 author R. O'Kennedy
  • Published 1997
  • Biology, Medicine
  • Cancer letters
  • A derivative of coumarin, 8-nitro-7-hydroxycoumarin (8-NO2-7-OHC), was synthesised, purified and characterised. The cytostatic and cytotoxic nature of this compound was determined using both human and animal cell lines grown in vitro for 96 h in the presence of drug (0-500 microM, equivalent to 0-104 microg/ml). 8-NO2-7-OHC was shown to be cytotoxic to three cell lines, but cytostatic to all cell lines tested. With K562 and HL-60 cells, cell death was found to occur by apoptosis. This cytotoxic… CONTINUE READING
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