Studies on the cofactor requirement for the acylation and hydrolysis reactions catalyzed by purified lecithin-cholesterol acyltransferase. Effect of low density lipoproteins and apolipoprotein A-i.

@article{Subbaiah1982StudiesOT,
  title={Studies on the cofactor requirement for the acylation and hydrolysis reactions catalyzed by purified lecithin-cholesterol acyltransferase. Effect of low density lipoproteins and apolipoprotein A-i.},
  author={Papasani V Subbaiah and Chang Hwei Chen and John J. Albers and John D Bagdade},
  journal={Atherosclerosis},
  year={1982},
  volume={45 2},
  pages={181-90}
}
Because lecithin-cholesterol acyltransferase (LCAT) has been shown to carry out acylation of lysolecithin as well as hydrolysis of lecithin in addition to an esterification of cholesterol, the cofactor requirements of the three reactions catalyzed by the enzyme were studied. The purified enzyme required apolipoprotein A-I (apo A-I) for both the… CONTINUE READING