Studies on the chronopharmacology of ethanol.

  title={Studies on the chronopharmacology of ethanol.},
  author={Meow-foo. Yap and David Mascord and Graham A. Starmer and John B. Whitfield},
  journal={Alcohol and alcoholism},
  volume={28 1},
Male subjects (n = 10) were given ethanol (0.75 g/kg) at four equally spaced times in the 24 hr cycle (9 am, 3 pm, 9 pm 3 am) in random order. Blood ethanol concentrations were monitored by breath analysis and measurements were made of the blood or plasma levels of ethanol, acetaldehyde, acetate, pyruvate, lactate and cortisol. Blood pressure, heart rate and body temperature were measured before and at 60 and 120 min after ethanol administration and the effects of ethanol on a number of… Expand
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