Studies on the chemistry, antitumor activity, and pharmacology of ethyl Di‐(2,2 ‐dimethyl)ethylenamido phosphate (AB‐163)

@article{Munson1969StudiesOT,
  title={Studies on the chemistry, antitumor activity, and pharmacology of ethyl Di‐(2,2 ‐dimethyl)ethylenamido phosphate (AB‐163)},
  author={A. Munson and H. Babbitt and Z. Chmielewicz and T. Bardos and J. Ambrus},
  journal={Journal of Surgical Oncology},
  year={1969},
  volume={1}
}
AB‐163, a new alkylating agent containing the 2,2‐dimethylaziridine moiety, was found to be active against a number of transplanted and virus‐induced tumor systems in mice. This compound hydrolyzes in water at 37 C. The hydrolysis product was isolated and identified as ethanol and amino‐tert‐butyl phosphate. The compound was shown to react with the model nucleophile 4‐(p‐nitrobenzyl) pyridine (NBP) comparably to previously studied alkylating agents. The intravenous LD50 was 198 mg/kg and the… Expand
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