Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Inductions of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III

@article{Avery1979StudiesOT,
  title={Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Inductions of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III},
  author={Oswald T. Avery and Colin M. Macleod and Maclyn Mccarty},
  journal={The Journal of Experimental Medicine},
  year={1979},
  volume={149},
  pages={297 - 326}
}
A reprint of Avery, MacLeod, and McCarty's article on the 35th anniversary of its original publication. The introduction is written by Joshua Lederberg. 
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1,922 Citations

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References

SHOWING 1-10 OF 46 REFERENCES
IN VITRO TRANSFORMATION OF PNEUMOCOCCAL TYPES : I. A TECHNIQUE FOR INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES IN VITRO.
TLDR
Previous findings on the thermal characteristics of the property of S vaccines responsible for transformation of type have been confirmed and extended.
DECOMPOSITION OF THE CAPSULAR POLYSACCHARIDE OF PNEUMOCOCCUS TYPE III BY A BACTERIAL ENZYME
TLDR
The specific decomposition of the capsular polysaccharide of Type III Pneumococcus, by the organism as well as by the enzyme it produces, illustrates once more the specificity of the types of P pneumococcus and confirms the fact that the Capsular Polysaccharides, and not some impurities carried along with them, are responsible for type specificity.
THE TRANSFORMATION OF PNEUMOCOCCAL TYPES : II. THE INTERCONVERTIBILITY OF TYPE-SPECIFIC S PNEUMOCOCCI.
TLDR
The ro1e which the phenomenon of transformation of type may play in problems of infection and epidemiology is indicated and the causes responsible for the transformations are discussed.
Advances in Enzymology and Related Subjects of Biochemistry
THE two volumes under review maintain the high standard of their predecessors. The subjects of the articles are varied, ranging from considerations of gene structure to a description of recent work…
THE USE OF GRADED COLLODION MEMBRANES FOR THE CONCENTRATION OF A BACTERIAL ENZYME CAPABLE OF DECOMPOSING THE CAPSULAR POLYSACCHARIDE OF TYPE III PNEUMOCOCCUS
TLDR
When enzyme solutions are filtered to dryness through membranes of such porosity as to hold back the active principle, and when proper precautions are taken to prevent or minimize adsorption, the enzyme can be completely recovered in solution by immersing the membrane in distilled water or physiological salt solution.
The preparation and use of the bone phosphatase.
THE phosphatase obtained from the bones of growing animals has proved very useful in the study of the chemical composition of phosphoric esters of biochemical interest. By its aid the phosphoric acid…
Outlines of biochemistry
TLDR
This chapter discusses the metabolism of nitrogen-containing Compounds, biosynthesis of Nucleic Acids, and the regulation of Gene Expression in non-cellular Organisms.
Genes and Chromosomes Structure and Organization.
Advances in enzymology and related subjects of biochemistry: F. F. Nord, Volume VIII, 1 vol., 1947, Interscience Publ., New York, 665 p
Handbuch der Virusforschung
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