Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Inductions of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III
@article{Avery1979StudiesOT, title={Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Inductions of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III}, author={Oswald T. Avery and Colin M. Macleod and Maclyn Mccarty}, journal={The Journal of Experimental Medicine}, year={1979}, volume={149}, pages={297 - 326} }
A reprint of Avery, MacLeod, and McCarty's article on the 35th anniversary of its original publication. The introduction
is written by Joshua Lederberg.
1,922 Citations
Transformation of encapsulated Streptococcus pneumoniae
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- 1986
This work describes the high-efficiency transformation of several virulent, encapsulated isolates of Streptococcus pneumoniae by the induction of competence with competence factor and was apparently the result both of inducing noncompetent recipients and overcoming the inhibition imposed by the capsule.
RELEASE OF GENETIC TRANSFORMING AGENT FROM PNEUMO- COCCAL CULTURES DURING GROWTH AND DISINTEGRATION* BY ELENA OTTOLENGHI,~ ProD., AND ROLLIN D. HOTCHKISS, ProD
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The present communication deals with the nature of the process of release of genetically active material from streptomycintreated and from untreated growing pneumococcal cultures.
From pneumonia to DNA: the research career of Oswald T. Avery.
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- 1993
In this article, Amsterdamska uses Avery and his research on bacterial transformation as a case study to assess how different
evidential contexts, institutional practices, and ideologies impact the…
Genetic characterisation of Streptococcus pneumoniae serotype 1 isolates in relation to invasiveness.
- Biology, Medicine
- 2010
Thesis (Ph.D.) -- University of Adelaide, School of Molecular and Biomedical Sciences, 2010
Traditional and molecular analyses of the genes encoding pneumococcal polysaccharide capsule production: cloning Avery's transforming principle
- Biology
- 1994
Following earlier work on transformation by Fred Griffith and others, Oswald Avery and colleagues showed that DNA, and not some other cellular component was responsible for the transformation of pneumococci from an unencapsulated to an encapsulated state.
Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Induction of transformation by a desoxyribonucleic acid fraction isolated from Pneumococcus type III. 1944.
- BiologyMolecular medicine
- 1995
Though scientists were initially skeptical that genes [8] were made of DNA, they later recognized that the data reported in “Transformation” were clear evidence that DNA was genetic material, a revelation that furthered research about how organisms grow, develop, and pass on traits to offspring.
A low affinity penicillin-binding protein 2 x is required for 1 heteroresistance in Streptococcus pneumoniae 2 3
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- 2014
Mechanisms of pneumococcal heteroresistance are studied for the first time in a large number of animals for the purposes of drug discovery and characterization.
Recent trends on the molecular biology of pneumococcal capsules, lytic enzymes, and bacteriophage.
- Biology, MedicineFEMS microbiology reviews
- 2004
Pathogenesis of pneumococcal infection.
- Medicine, BiologyThe New England journal of medicine
- 1995
The observation that noncapsulated pneumococci caused progressive disease in rabbits with agranulocytosis, demonstrating thereby the pathogenic properties of the pneumococcal soma, was of comparable importance.
Development of an in vivo selection system for the identification of antibacterial cyclic peptides
- Biology, Engineering
- 2015
An in vivo screening assay is described, which allows the identification of bioactive cyclic peptides that specifically bind to the Salmonella typhimurium riboswitch and thereby inhibit downstream gene expression.
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