Studies on the biosynthesis of fosfomycin. 4. The biosynthetic origin of the methyl group of fosfomycin.

@article{Kuzuyama1992StudiesOT,
  title={Studies on the biosynthesis of fosfomycin. 4. The biosynthetic origin of the methyl group of fosfomycin.},
  author={Tomohisa Kuzuyama and Tomomi Hidaka and Kazuma Kamigiri and Satoshi Imai and Haruo Seto},
  journal={The Journal of antibiotics},
  year={1992},
  volume={45 11},
  pages={
          1812-4
        }
}
Fosfomycin (FM) is a clinically useful antibiotic produced by several Streptomyces species2'3*, Pseudomonas syringae^ and Pseudomonas viridiflava5). This small compound has a unique structure, including a carbon-phosphorus bond (C-P bond) and an epoxide6). Recently we proved that the C-P bond in FM was formed by intramolecular rearrangement of phosphoenolpyruvate (PEP) to phosphonopyruvate catalyzed by PEP phosphomutase (Fig. 1 (1))1} utilizing a mechanism commonto the formation of other… 

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TLDR
Results demonstrate that themtmMI and mtmMII genes code for two S-adenosylmethionine-dependent methyltransferases responsible for the 4-O-methylation and 9-C- methylation steps of the biosynthetic precursors 4-DPMC and9-DPMA3, respectively, of the antitumor drug mithramycin.
Stereoselective epoxidation of cis-propenylphosphonic acid to fosfomycin by a newly isolated bacterium Bacillussimplex strain S101
TLDR
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Biosynthetic pathways and enzymes involved in the production of phosphonic acid natural products.
TLDR
The biosynthesis of FM is reviewed, which includes a recent breakthrough to find a missing link in the biosynthetic pathway that had been a mystery for a quarter-century and the genome mining of phosphonate natural products using the biosynthesis gene encoding an enzyme that catalyzes C-P bond formation.
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Phosphoenolpyruvate phosphomutase (PEPPM) catalyzes the C-P bond forming reaction by intramolecular rearrangement of phosphoenolpyruvate to phosphonopyruvate, and shows stronger activity in
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The antibiotic fosfomycin was produced as a secondary metabolite in a glucose-asparagine medium containing citrate, l-methionine, and l-glutamate, and radioactive incorporation studies showed that the methyl carbon of methionine was the precursor of the methyl of fosFomycin.
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THE CHEMISTRY OF Co(I) DERIVATIVES OF VITAMIN B12 AND OF RELATED CHELATES
  • G. Schrauzer
  • Chemistry
    Annals of the New York Academy of Sciences
  • 1969
The main points of the present review can be summarized as follows:
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