Studies on the biosynthesis of fosfomycin. 4. The biosynthetic origin of the methyl group of fosfomycin.

  title={Studies on the biosynthesis of fosfomycin. 4. The biosynthetic origin of the methyl group of fosfomycin.},
  author={Tomohisa Kuzuyama and Tomomi Hidaka and Kazuma Kamigiri and Satoshi Imai and Haruo Seto},
  journal={The Journal of antibiotics},
  volume={45 11},
Fosfomycin (FM) is a clinically useful antibiotic produced by several Streptomyces species2'3*, Pseudomonas syringae^ and Pseudomonas viridiflava5). This small compound has a unique structure, including a carbon-phosphorus bond (C-P bond) and an epoxide6). Recently we proved that the C-P bond in FM was formed by intramolecular rearrangement of phosphoenolpyruvate (PEP) to phosphonopyruvate catalyzed by PEP phosphomutase (Fig. 1 (1))1} utilizing a mechanism commonto the formation of other… 

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  • G. Schrauzer
  • Chemistry
    Annals of the New York Academy of Sciences
  • 1969
The main points of the present review can be summarized as follows: