Studies on the biliary efflux of GSH from rat liver due to the metabolism of aminopyrine.

@article{Krieter1985StudiesOT,
  title={Studies on the biliary efflux of GSH from rat liver due to the metabolism of aminopyrine.},
  author={Philip A. Krieter and Daniel M. Ziegler and K. E. Hill and Raymond F. Burk},
  journal={Biochemical pharmacology},
  year={1985},
  volume={34 7},
  pages={
          955-60
        }
}
  • Philip A. Krieter, Daniel M. Ziegler, +1 author Raymond F. Burk
  • Published 1985
  • Chemistry, Medicine
  • Biochemical pharmacology
  • The biliary efflux of GSH and GSSG due to aminopyrine was studied using perfused rat livers. The infusion of 0.8 mM aminopyrine led to a rapid rise in the amount of GSH released into the bile with only a small increase in the amount of GSSG released; caval GSH + GSSG efflux was unaffected. N-Benzylimidazole, an inhibitor of cytochrome P-450, completely blocked the response while phenobarbital pretreatment of the rats doubled the rate of GSH efflux. H2O2 and selenium-containing glutathione… CONTINUE READING