Studies on the antitumor activity of gallium nitrate (NSC-15200) and other group IIIa metal salts.

@article{Adamson1975StudiesOT,
  title={Studies on the antitumor activity of gallium nitrate (NSC-15200) and other group IIIa metal salts.},
  author={Richard H. Adamson and George Peter Canellos and Susan M. Sieber},
  journal={Cancer chemotherapy reports},
  year={1975},
  volume={59 3},
  pages={599-610}
}
Several group IIIa metal salts, eg, aluminum nitrate, gallium nitrate, indium nitrate, and thallium chloride, have been evaluated for in vivo toxicity in mice and rats, for cytotoxicity in tumor cells in vitro, and for activity against a broad spectrum of experimental rodent tumors. The position of these agents in the periodical table roughly parallels their toxicity, the LD50s decreasing with increasing atomic weights. This parallel also exists with regard to in vitro cytotoxicity to Walker… CONTINUE READING
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