Studies on the antimutagenic activity of ascorbic acid in vitro and in vivo.

@article{Norkus1985StudiesOT,
  title={Studies on the antimutagenic activity of ascorbic acid in vitro and in vivo.},
  author={Edward P. Norkus and W A Kuenzig},
  journal={Carcinogenesis},
  year={1985},
  volume={6 11},
  pages={
          1593-8
        }
}
The possibility that ascorbic acid, as a nucleophile, may inhibit mutagenicity induced by electrophilic metabolites of N-nitroso compounds was examined. In vitro data are presented to show that ascorbic acid does not decrease the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in a modified Ames bacterial mutagenicity system if deionized water is used to prepare the incubation medium. However, ascorbic acid prevents the mutagenicity of MNNG in vitro if added to bacteria in a medium… CONTINUE READING