Studies on the alkaloid constituents of Evodia rutaecarpa (Juss) Benth var. bodinaieri (Dode) Huang and their acute toxicity in mice

  title={Studies on the alkaloid constituents of Evodia rutaecarpa (Juss) Benth var. bodinaieri (Dode) Huang and their acute toxicity in mice},
  author={X-W Yang and Huiping Zhang and M. Li and L Du and Z. Yang and Shi-ying Xiao},
  journal={Journal of Asian Natural Products Research},
  pages={697 - 703}
Six alkaloids (1–6) have been isolated from the fruits of Evodia rutaecarpa (Juss) Benth var. bodinaieri (Dode) Huang, two of which are new compounds, identified as 2-undecyl-4(1H)-quinolone (4) and 1-methyl-2-undecanone-10′-4(1H)-quinolone (5); the known compounds were identified as rutaecarpine (1), evodiamine (2), 1-methyl-2-undecyl-4(1H)-quinoline (3) and 2-undecanone-10′-4(1H)-quinolone (6). Compounds 1–5 were evaluated for their acute toxicity. 
Separation and Purification of Quinolone Alkaloids from the Chinese Herbal Medicine Evodia rutaecarpa (Juss.) Benth by High Performance Counter-Current Chromatography
Preparative separation of quinolone alkaloids in Evodia rutaecarpa (Juss.) Benth was conducted by high performance counter-current chromatography (HPCCC) with a pair of two solvent systems consistingExpand
Indoloquinazoline alkaloids from Euodia rutaecarpa and their cytotoxic activities
Nine indoloquinazoline alkaloids were isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth and evaluated for their cytotoxic activities against human promyelocytic leukemia HL-60 cells and human gastric carcinoma N-87 cells. Expand
New cytotoxic quinolone alkaloids from fruits of Evodia rutaecarpa.
The cytotoxic activities of the compounds against the human cancer cell lines HL-60, N-87, H-460, and Hep G(2) cells were evaluated by MTT assay and showed that these alkaloids inhibited cell proliferation with IC(50) values between 14μM and 22μM. Expand
Limonoid constituents of Euodia rutaecarpa var. bodinieri and their inhibition on NO production in lipopolysaccharide-activated RAW264.7 macrophages
A new limonoid compound, named evorubodinin (1), was isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang (family Rutaceae), together withExpand
New glycosidic alkaloid from the nearly ripe fruits of Euodia rutaecarpa
Two new natural product and a rarely new glycosidic alkaloid were isolated from the butanol fraction of 70% ethanol aqueous extract of the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth and their structures were elucidated on the basis of their spectroscopic data. Expand
A new indoloquinazoline alkaloidal glucoside from the nearly ripe fruits of Evodia rutaecarpa
A new indoloquinazoline alkaloid glucoside, rutaecarpine-10-O-β-d-glucopyranoside, together with one known alkaloidal glycoside, was isolated from the nearly ripe fruits of Evodia rutecarpa (Juss.) Benth. Expand
Fatty Acid Components of Hardy Kiwifruit (Actinidia arguta) as IL-4 Production Inhibitor
【The fruit of Actinidia arguta (AA) has been used mainly for the treatment of skin diseases, diuresis, diabetes mellitus and osteoporosis in Korean traditional medicine. It is known that AA (hardyExpand
Evodiamine: A Novel Anti-Cancer Alkaloid from Evodia rutaecarpa
Growing evidence demonstrates that evodiamine possesses anti-cancer activities both in vitro and in vivo by inhibiting proliferation, invasion and metastasis, inducing apoptosis of a variety of tumor cell lines. Expand
Cytochrome P450 Mediated Bioactivation of Rutaevin, a Bioactive and Potentially Hepatotoxic Component of Evodia Rutaecarpa.
Investigation of the bioactivation of rutaevin in rat and human liver microsomes fortified with NADPH found that ruta Devin was a mechanism-based inactivator of CYP3A4, with inactivation parameters of KI = 15.98 μM, kinact = 0.032 min-1, and t1/2 inact = 21.65 min. Expand
Genus Tetradium L.: A comprehensive review on traditional uses, phytochemistry, and pharmacological activities.
Phytochemical and pharmacological studies of Tetradium plants have proved Tetradan plants are important medicinal herb resource, however, well-designed randomized clinical trials are necessary to confirm the therapeutic benefits of this genus in clinical settings. Expand


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234 (sh), 213 (3.54). IR (KBr) n max
  • Colorless needles (EtOAc), mp 260 -2618C, C 18 H 13 N 3 O. UV (EtOH) l max (nm) (log e): 362 (3.46)
58 (1H, dd
  • J ¼
A white amorphous powder, C 20 H 27 NO 2 . UV (MeOH) l max (nm)
    A white amorphous powder, C 20 H 29 NO. UV (MeOH) l max (nm)