Studies on the adrenocorticotropic hormone-activated adenyl cyclase of a functional adrenal tumor.

@article{Taunton1969StudiesOT,
  title={Studies on the adrenocorticotropic hormone-activated adenyl cyclase of a functional adrenal tumor.},
  author={O. David Taunton and Jesse Roth and Ira Pastan},
  journal={The Journal of biological chemistry},
  year={1969},
  volume={244 2},
  pages={
          247-53
        }
}
Abnormal hormone responses of an adrenocortical cancer adenyl cyclase.
  • I. Schorr, R. Ney
  • Medicine, Biology
    The Journal of clinical investigation
  • 1971
TLDR
The cyclase of the tumor as well as of the adrenals was stimulated by adrenocorticotropic hormone (ACTH) over similar concentration ranges, and the tumor enzyme was also stimulated by epinephrine, norepinephrine, and thyroid-stimulating hormone (TSH).
Effects of Calcium on ACTH Stimulation of the Adrenal: Separation of Hormone Binding from Adenyl Cyclase Activation
TLDR
Calcium is thought to be required for the binding of adrenal corticotrophic hormone (ACTH) to its cellular receptor and inhibit the activation of adenyl cyclase by ACTH in subcellular particles from adipose and adrenal tissue.
ACTH‐RECEPTOR INTERACTION IN THE ADRENAL: A MODEL FOR THE INITIAL STEP IN THE ACTION OF HORMONES THAT STIMULATE ADENYL CYCLASE
TLDR
The evidence for hormone receptors in relation to the adenyl cyclase system is reviewed, a detailed description of the interaction of ACTH with its physiological receptors in adrenal cortical tissue is presented, and the ACTH system is used as a model to speculate further on the nature and role of hormone receptors.
Multiple hormone receptors in the adenylate cyclase of human adrenocortical tumors.
TLDR
The results indicate the presence of multiple receptors for hormones other than ACTH and PGE1, the normal adrenocortical stimulants, in human adrenocortsical tumors, particularly in adrenal adenomas, but not in normal and hyperplastic adrenal tissues, suggesting a functional alteration of the cellular membrane receptors in human adrenaline tumors.
Adenyl cyclase and hormone action. 3. Calcium requirement for ACTH stimulation of adenyl cyclase.
  • H. Bär, O. Hechter
  • Biology, Medicine
    Biochemical and biophysical research communications
  • 1969
Hormone Action on Liver Adenyl Cyclase Activity
TLDR
The data suggest enhanced transmission of the hormone signal from the (hypothetical) receptor to the catalytic enzyme unit by chelation of membrane bound calcium by chelated calcium by the adenyl cyclase system.
The effect of calcium concentration on ACTH stimulation of steroidogenesis in mouse adrenal tumor cells
TLDR
These experiments support the concept that calcium is important at the level of ACTH‐membrane receptor site interaction or activation of adenyl cyclase in adrenal tumor cells.
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    Jesse Roth and Ira Pastan Functional Adrenal Tumor Studies on the Adrenocorticotropic Hormone-activated Adenyl Cyclase of a
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